Imidazole ketone erastin
Catalog No.
C8432
A potent, metabolically stable systemic xc- inhibitor and iron apoptosis inducer
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Imidazoleketone erastin (IKE) is a novel anticancer drug that works primarily by inducing iron death (ferroptosis). Iron death is a kind of iron dependent cell programmed death, which is different from the traditional apoptosis mechanism. IKE induces cell death by inhibiting the activity of glutathione peroxidase 4 (GPX4), leading to the accumulation of intracellular lipid peroxides. Because many cancer cells are sensitive to iron death, IKE shows potential in cancer treatment, especially in cancer types that are resistant to traditional therapies. In addition, the selective mechanism of action of IKE makes it less toxic in normal cells, increasing its application prospects as an anticancer drug.
| Storage | Desiccate at 4°C away from light for 2 years. |
| M.Wt | 655.15 |
| Cas No. | 1801530-11-9 |
| Formula | C35H35ClN6O5 |
| Synonyms | IKE |
| Solubility | ≥48.4 mg/mL in DMSO; ≥39.4 mg/mL in EtOH; insoluble in H2O |
| Chemical Name | 3-(5-(2-(1H-imidazol-1-yl)acetyl)-2-isopropoxyphenyl)-2-((4-(2-(4-chlorophenoxy)acetyl)piperazin-1-yl)methyl)quinazolin-4(3H)-one |
| SDF | Download SDF |
| Canonical SMILES | O=C1N(C2=CC(C(CN3C=CN=C3)=O)=CC=C2OC(C)C)C(CN4CCN(C(COC5=CC=C(Cl)C=C5)=O)CC4)=NC6=CC=CC=C61 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
