IDOR-1117-2520
IDOR‑1117‑2520 (CAS No.: 2737274-49-4) is an orally active, potent, selective, reversible CCR6 antagonist. CCR6 is a chemokine receptor mainly expressed on pathogenic T17 cells (Th17/Tc17, etc.) and some B cells. In autoimmune diseases such as psoriasis, these CCR6⁺ cells are recruited to target tissues such as inflamed skin or lung through the CCL20–CCR6 axis. IDOR‑1117‑2520 binds to and blocks CCR6, inhibiting the chemotactic response of CCR6⁺ immune cells to CCL20, thereby preventing their migration to and infiltration into inflamed tissues. In Aldara- and IL‑23-induced mouse models of skin inflammation, IDOR‑1117‑2520 dose-dependently reduced the infiltration of CCR6⁺ immune cells into inflamed skin, with anti-inflammatory effects comparable to direct blockade of IL‑17 or IL‑23.
References:
[1] Meyer EA, Croxford AL, Gnerre C, Kulig P, Murphy MJ, Jacob EM, Schäfer G, Richard-Bildstein S, Aissaoui H, Bouis P, Ertel EA, de Kanter R, Keller MP, Lüthi U, Caroff E. Discovery of the Clinical Candidate IDOR-1117-2520: A Potent and Selective Antagonist of CCR6 for Autoimmune Diseases. J Med Chem. 2024 May 23;67(10):8077-8098. doi: 10.1021/acs.jmedchem.4c00186. Epub 2024 May 10. PMID: 38727100.
[2] Kulig P, Brazauskas P, Suffiotti M, Raoult E, Babilonski U, Renault B, Grieder U, Vezzali E, Blattmann P, Martinic MM, Murphy MJ. Efficacy of IDOR-1117-2520, a novel, orally available CCR6 antagonist in preclinical models of skin dermatitis. Br J Pharmacol. 2025 Aug;182(15):3452-3475. doi: 10.1111/bph.70025. Epub 2025 Mar 28. PMID: 40156059.
| Storage | Store at -20°C |
| M.Wt | 436.55 |
| Cas No. | 2737274-49-4 |
| Formula | C25H32N4O3 |
| Chemical Name | (R)-2-(3-(5-((1,3-dimethylazetidin-3-yl)(hydroxy)(4-isopropylphenyl)methyl)pyridin-3-yl)-1,2,4-oxadiazol-5-yl)propan-2-ol |
| Canonical SMILES | CC(C1=CC=C([C@@](C2=CC(C3=NOC(C(C)(O)C)=N3)=CN=C2)(O)C4(CN(C4)C)C)C=C1)C |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |