HRO761
Catalog No.
A9929
A DNA helicase inhibitor
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HRO761 is a potent RecQ DNA helicase (WRN) inhibitor in Werner syndrome, with significant anticancer potential. WRN helicase plays a key role in the process of DNA replication, repair and recombination, and its abnormal activity is closely related to the occurrence and development of many cancers. HRO761 interferes with the DNA repair mechanism of cancer cells by specifically inhibiting the activity of WRN, thereby inhibiting their proliferation and growth.
| Storage | Store at -20°C for 3 years. |
| M.Wt | 702.09 |
| Cas No. | 2869954-34-5 |
| Formula | C31H31ClF3N9O5 |
| Solubility | ≥25.3 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O |
| Chemical Name | N-(2-chloro-4-(trifluoromethyl)phenyl)-2-(2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-6-(4-(5-hydroxy-6-methylpyrimidine-4-carbonyl)piperazin-1-yl)-7-oxo-[1,2,4]triazolo[1,5-a]pyrimidin-4(7H)-yl)acetamide |
| SDF | Download SDF |
| Canonical SMILES | OC1=C(C)N=CN=C1C(N2CCN(C(C(N3C(N4CC(NC5=CC=C(C(F)(F)F)C=C5Cl)=O)=NC(C6=CCOCC6)=N3)=O)=C4CC)CC2)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
