Hemin chloride
Hemin chloride (CAS: 16009-13-5) is a small-molecule modulator targeting eukaryotic translation initiation factors and heme oxygenase-1 (HO-1). It acts by inhibiting eukaryotic translation initiation factor 2α kinase 1 (eIF2αK1) and inducing HO-1 expression, thereby influencing translational regulation and heme metabolism pathways.
Hemin chloride exerts its biological activity primarily by inhibiting the phosphorylation of eIF-2α and eIF-2β and inducing HO-1. In vitro, the addition of 25–30 μM hemin chloride decreases phosphate incorporation into eIF-2α/β by approximately 50% and maintains optimal protein synthesis rates in cell lysates at 20–40 μM concentrations. In vivo, intraperitoneal injection in mice induces HO-1 expression and delays thrombus formation.
Hemin chloride holds research potential in studies of protein synthesis, acute intermittent porphyria, and thrombotic disease mechanisms.
- 1. Cuiying Peng, Yilin Wang, et al. "Selective HDAC6 inhibition protects against blood–brain barrier dysfunction after intracerebral hemorrhage." CNS Neurosci Ther. 2023 Sep 4. PMID: 37665135
- 2. Yan Huang, Jianyang Liu, et al. "Curcumin preconditioning enhances the neuroprotective effects of olfactory mucosa-derived mesenchymal stem cells on experimental intracerebral hemorrhage." Heliyon. 2023 Jul 3;9(7):e17874. PMID: 37483835
| Physical Appearance | A crystalline solid |
| Storage | Store at 2-8°C |
| M.Wt | 652.0 |
| Cas No. | 16009-13-5 |
| Formula | C34H30ClFeN4O4·2H |
| Solubility | ≥26.5 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O |
| Chemical Name | (SP-5-13)-chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,8-dipropanoato(4-)-κN21, κN22, κN23, κN24]-ferrate(2-), dihydrogen |
| SDF | Download SDF |
| Canonical SMILES | [O-]C(CCC1=C(C=C2[N]3=C4C(C)=C2CCC([O-])=O)[N-]([Fe+3]35([Cl-])[N]6=C7C=C(C(C=C)=C8C)[N-]5C8=C4)C(C=C6C(C=C)=C7C)=C1C)=O.[H+].[H+] |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
