Guvacoline (hydrobromide)
Target: atrial and ileal muscarinic receptors
IC50: 2.1 mM for growth inhibition of human buccal epithelial cells
Guvacoline is a kind of natural alkaloid which is found in areca nuts that is related to the nootropic, arecoline. Guvacoline can function as a full agonist of atrial and ileal muscarinic receptors.
In Vitro: In human buccal epithelial cells, Guvacoline could significantly decrease the colony-formation efficiency in a dose dependent manner, with the IC50 value of 2.1 mM. Besides, Guvacoline could also dose-dependently reduce the amount of total free low-molecular-weight thiols (0.88 mM Guvacoline caused 25% decrease) and increase the number of single strand breaks [1].
In Vivo: No data available recently.
Clinical trial: No data available recently.
Reference:
[1] K. Sundqvist, Y. Liu, J. Nair, et al. Cytotoxic and genotoxic effects of areca nut-related compounds in cultured human buccal epithelial cells. Cancer Research 49(19), 5294-5298 (1989).
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 222.1 |
| Cas No. | 17210-51-4 |
| Formula | C7H11NO2·HBr |
| Synonyms | Norarecoline |
| Solubility | ≤1mg/ml in DMSO;1mg/ml in dimethyl formamide |
| Chemical Name | 1,2,5,6-tetrahydro-3-pyridinecarboxylic acid, methyl ester, monohydrobromide |
| SDF | Download SDF |
| Canonical SMILES | O=C(OC)C1=CCCNC1.Br |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
- Datasheet
Chemical structure
Related Biological Data
