GNE-987
Catalog No.
BA4683
GNE-987 is a PROTAC linked by a ligand and a
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GNE-987 is a ligand- and ligand-conjugated PROTAC.GNE-987 displays picomolar cellular degradation activity (=0.03 nM in the EOL-1AML cell line).GNE-987 binds to BD1 and BD2 of BRD4 with low nanomolar affinity (4.7 and 4.4 nM, respectively). It contains a potent BET-binding agent/inhibitor, a VHL-binding fragment, and a ten-methylene spacer group portion.GNE-987 was used in a PROTAC-Antibody coupling (PAC).
| Physical Appearance | A solid |
| Storage | 4°C |
| M.Wt | 1096.31 |
| Cas No. | 2417371-71-0 |
| Formula | C56H67F2N9O8S2 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |