Glucosylceramide, plant
Glucosylceramide, plant (CAS No.: 497155-61-0) is a plant-derived glucosylceramide and a precursor for the synthesis of more complex glycosphingolipids (e.g., lactosylceramide, gangliosides), playing important roles in membrane structure, barrier function, and cellular signaling regulation.
Cell level: Commonly used in vitro as a reagent for studying sphingolipid metabolism and signaling or as an exogenous lipid supplement: it can affect cell proliferation, differentiation, and apoptosis, regulate inflammation and immune responses, and is also used to investigate the role of glucosylceramide in insulin resistance, tumorigenesis, and neuronal cell function.
Animal level: Plant-derived Glucosylceramide is mostly used in oral or transdermal supplementation models to evaluate its effects on improving skin barrier function and moisturization, protecting the intestinal mucosa, and modulating the gut microbiota; it is also used in obesity/diabetes and neurodegenerative disease models to explore the causal relationship between elevated tissue glucosylceramide and metabolic dysregulation and abnormal neural function.
References:
[1] Holland WL, Summers SA. Sphingolipids, insulin resistance, and metabolic disease: new insights from in vivo manipulation of sphingolipid metabolism. Endocr Rev. 2008 Jun;29(4):381-402. doi: 10.1210/er.2007-0025. Epub 2008 May 1. PMID: 18451260; PMCID: PMC2528849.
[2] Cahoon EB, Lynch DV. Analysis of Glucocerebrosides of Rye (Secale cereale L. cv Puma) Leaf and Plasma Membrane. Plant Physiol. 1991 Jan;95(1):58-68. doi: 10.1104/pp.95.1.58. PMID: 16667981; PMCID: PMC1077485.
[3] Lynch DV, Dunn TM. An introduction to plant sphingolipids and a review of recent advances in understanding their metabolism and function. New Phytol. 2004 Mar;161(3):677-702. doi: 10.1111/j.1469-8137.2004.00992.x. Epub 2004 Jan 14. PMID: 33873728.
[4] Dai M, Liou B, Swope B, Wang X, Zhang W, Inskeep V, Grabowski GA, Sun Y, Pan D. Progression of Behavioral and CNS Deficits in a Viable Murine Model of Chronic Neuronopathic Gaucher Disease. PLoS One. 2016 Sep 6;11(9):e0162367. doi: 10.1371/journal.pone.0162367. PMID: 27598339; PMCID: PMC5012639.
| Storage | Store at -20°C |
| M.Wt | 714.04 |
| Cas No. | 497155-61-0 |
| Formula | C40H75NO9 |
| Synonyms | GluCer (soy) |
| Chemical Name | 2-hydroxy-N-((2S,3R,4E,8E)-3-hydroxy-1-(((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)octadeca-4,8-dien-2-yl)hexadecanamide |
| Canonical SMILES | O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](OC[C@@H]([C@H](O)/C=C/CC/C=C/CCCCCCCCC)NC([R])=O)[C@@H]1O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |