Geranyl Pyrophosphate (triammonium salt)

Geranyl Pyrophosphate (triammonium salt) (CAS No.: 116057-55-7) is a biologically active isoprenoid intermediate that occupies a central position in the isoprenoid biosynthesis pathway, serving as a key precursor for the generation of a wide range of sterol and non-sterol isoprenoids. Endogenously derived from the condensation of isopentenyl pyrophosphate and dimethylallyl pyrophosphate, it functions as a critical substrate for multiple prenyltransferases and terpene synthases, thereby contributing to the biosynthesis of essential biomolecules including cholesterol, ubiquinones, dolichols, and various prenylated proteins. Through its role in these enzymatic processes, it is closely associated with pathways regulating membrane integrity, protein prenylation, and cellular signaling networks. In biochemical and pharmacological research, this compound is widely utilized to investigate enzyme kinetics, substrate specificity, and regulatory mechanisms within isoprenoid metabolism, as well as to support studies of metabolic flux and pathway modulation in cellular and in vitro systems. Although direct activity metrics such as inhibitory or activation constants are not typically defined for this endogenous intermediate, experimental applications often employ concentrations in the nanomolar to micromolar range depending on assay design and biological context. Its utility extends to drug discovery efforts targeting enzymes of the isoprenoid pathway, enabling mechanistic exploration of metabolic disorders, antimicrobial targets, and cancer-associated dysregulation of prenylation processes.