FTY720 (S)-Phosphate

FTY720 (S)-Phosphate (CAS No.: 402616-26-6) is a bioactive sphingosine analog metabolite and the pharmacologically active, phosphorylated stereoisomer of FTY720, classified as a selective agonist of sphingosine-1-phosphate receptor 1 (S1PR1) with additional activity at S1PR3, S1PR4, and S1PR5. It modulates S1P signaling pathways by inducing receptor internalization on lymphocytes, thereby inhibiting S1P-dependent lymphocyte egress from lymphoid tissues and exerting potent immunomodulatory effects. The compound demonstrates high-affinity receptor binding in the nanomolar range and is widely used to investigate S1P-mediated regulation of immune cell trafficking, endothelial barrier integrity, and inflammatory signaling. Mechanistically, it has been shown to enhance endothelial barrier function, influence transporter activity including Abcb1 and Abcc1, and suppress cytosolic phospholipase A2 activity, collectively contributing to its anti-inflammatory profile. FTY720 (S)-Phosphate is extensively applied in both in vitro and in vivo models to study acute inflammatory conditions such as acute lung injury, as well as broader immune and vascular responses, making it a valuable tool in immunology and drug discovery research. Experimental concentrations and dosing regimens vary depending on the specific cellular or animal model and the intended investigative endpoints.