Fluticasone Furoate
Fluticasone furoate is a high-affinity synthetic glucocorticoid, commonly used in inhalation formulations for the treatment of asthma and allergic rhinitis. It is a GR receptor agonist; after binding to cytoplasmic GR, it translocates into the nucleus and binds to GRE to upregulate anti-inflammatory genes, downregulate the expression of inflammatory factors such as IL‑4, IL‑5, IL‑13, and TNF‑α, and inhibit the recruitment of inflammatory cells such as eosinophils and T cells. Its ester group structure increases lipophilicity and receptor affinity, providing a long local duration of action and enabling once-daily dosing; systemic exposure is low, but long-term use at high doses still requires monitoring for HPA axis suppression and local fungal infections.
| Storage | Store at -20°C |
| M.Wt | 538.58 |
| Cas No. | 397864-44-7 |
| Formula | C27H29F3O6S |
| Chemical Name | (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-17-(((fluoromethyl)thio)carbonyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl furan-2-carboxylate |
| SDF | Download SDF |
| Canonical SMILES | O(C(=O)C1=CC=CO1)[C@@]2(C(SCF)=O)[C@]3(C)[C@@](C[C@H]2C)([C@]4([C@](F)([C@@H](O)C3)[C@]5(C)C([C@@H](F)C4)=CC(=O)C=C5)[H])[H] |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |