FK-409

FK-409 (CAS No.: 138472-01-2) is a microbially derived nitric oxide (NO) donor and orally active vasodilatory agent widely utilized in cardiovascular research. It exerts its pharmacological effects primarily through the controlled release of NO, leading to activation of the soluble guanylate cyclase–cyclic GMP signaling pathway and subsequent relaxation of vascular smooth muscle cells, thereby modulating vascular tone and hemodynamics. FK-409 releases NO in a time-dependent manner under physiological conditions, with a reported half-life of approximately 40 minutes in buffered systems, and demonstrates inhibitory activity against platelet aggregation at low micromolar concentrations, supporting its role in studies of thrombosis and vascular function. As a representative NO donor, it is frequently employed to investigate mechanisms underlying cardiovascular diseases, including endothelial dysfunction, regulation of blood flow, and NO-mediated signaling pathways. In experimental settings, FK-409 is used across a range of in vitro and in vivo models to evaluate vasorelaxation, platelet activity, and related physiological responses, with applied concentrations or dosing regimens varying according to specific study designs and research objectives.