FGF-21, murine recombinant
Fibroblast growth factor 21 (FGF-21) is a member of the FGF family that contains more than 20 small (~17–26 kDa) secreted peptides. FGF-21 is mainly secreted by the liver and can travel through the circulatory system and function as an endocrine hormone. FGFs modulate cellular activity via 5 distinct subfamilies of high-affinity FGF receptors (FGFRs): FGFR-1, -2, -3, -4 and -5. FGFRs play an important role in the regulation of glucose and lipid homeostasis. FGF-21 is a potent activator of glucose uptake on adipocytes, protects animals from diet-induced obesity, and lowers blood glucose and triglyceride levels in diabetic rodents.
Mouse FGF-21 is a 210 amino acid (aa) polypeptide that contains a 120 aa core FGF domain and a hydrophobic N-terminus signal sequence that is cleaved to release the soluble 180 aa mature FGF-21 protein. Recombinant mouse FGF-21 produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 183 amino acids including N-terminal Methionine. The amino acid sequence of the recombinant mouse FGF-21 is 100% homologous to the amino acid sequence of the mouse FGF-21 without signal sequence. The FGF-21 is purified by proprietary chromatographic techniques.
Quality Control & DataSheet
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Purity: ≥95%, by SDS-PAGE and HPLC.
Endotoxin Level:N/A
Related Biological Data
Related Biological Data
| Gene ID: | 56636 | Accession #: | Q9JJN1 |
| Alternate Names: | mouse FGF-21, FGF-21, FGF21, FGF 21, m-FGF-21, rm-FGF-21, recombinant mouse FGF-21, recombinant FGF-21, FGF. | ||
| Source: | Escherichia Coli. | M.Wt: | 20.1 kDa |
| Appearance: | Lyophilized protein | Storage: | Store at -20°C |
| Formulation: | Lyophilized from filtered (0.4 mm) solution containing 20 mM Tris, pH 7.4 and 20 mM NaCl. | ||
| Solubility: | Reconstitute in sterile H2O to a concentration ≥ 100 µg/ml. This solution can then be diluted into other aqueous buffers and stored at 4℃ for 1 week or -20℃ for future use. | ||
| Shipping Condition: | gel pack. | Handling: | Centrifuge the vial prior to opening. |
| Usage: | For Research Use Only! Not to be used in humans. | ||