Fexofenadine HCl
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 538.12 |
| Cas No. | 153439-40-8 |
| Formula | C32H39NO4·HCl |
| Solubility | insoluble in H2O; ≥26.91 mg/mL in DMSO; ≥51.2 mg/mL in EtOH |
| Chemical Name | 2-[4-[1-hydroxy-4-[4-[hydroxy(diphenyl)methyl]piperidin-1-yl]butyl]phenyl]-2-methylpropanoic acid;hydrochloride |
| SDF | Download SDF |
| Canonical SMILES | CC(C)(C1=CC=C(C=C1)C(CCCN2CCC(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O)O)C(=O)O.Cl |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Cell experiment:[1] | |
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Cell lines |
HCT116 and COLO205 cells |
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Reaction Conditions |
10 or 50 μg/mL fexofenadine for 18 or 24 h incubation |
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Applications |
Fexofenadine (24 h incubation) significantly inhibited the upregulated expression of IL-8 in HCT116 and COLO205 cells stimulated with TNF-α. Fexofenadine (18 h incubation) also suppressed nuclear factor-κB DNA-binding activity in TNF-α-stimulated HCT116 cells. |
| Animal experiment:[1] | |
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Animal models |
C57BL/6NCrljBgi female mice, 6 ~ 7 weeks old |
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Dosage form |
2 or 10 mg/kg Once daily by oral gavage |
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Applications |
Oral administration of fexofenadine (2 or 10 mg/kg) reduced severity of colitis and phospho-IκB kinase activation in a mouse model of colitis induced by dextran sulfate sodium. These results suggest that fexofenadine is a potential therapeutic agent for the treatment of inflammatory bowel disease. |
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Note |
The technical data provided above is for reference only. |
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References: 1. Koh SJ, Kim JW, Kim BG, et al. Fexofenadine regulates nuclear factor-κB signaling and endoplasmic reticulum stress in intestinal epithelial cells and ameliorates acute and chronic colitis in mice. Journal of Pharmacology and Experimental Therapeutics, 2015, 352(3): 455-461. |
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Quality Control & MSDS
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Chemical structure
