Eugenol
Eugenol (CAS 97-53-0) is a small-molecule modulator that exerts its biological activity by modulating intracellular glutathione (GSH) levels, interrupting gap-junctional intercellular communication (GJIC), and inducing reactive oxygen species (ROS). It disrupts mitochondrial membrane potential (MMP) at concentrations between 10 and 100 μM and, at higher doses, affects intracellular calcium homeostasis and pH stability.
Eugenol is widely used in the mitigation of oxidative stress, gastric ulcer prevention, and dental endodontic applications.
References:
[1] Thompson DC,Barhoumi R,Burghardt RC. Comparative toxicity of eugenol and its quinone methide metabolite in cultured liver cells using kinetic fluorescence bioassays. Toxicol Appl Pharmacol.1998 Mar;149(1):55-63.
[2] Morsy MA,Fouad AA. Mechanisms of gastroprotective effect of eugenol in indomethacin-induced ulcer in rats. Phytother Res.2008 Oct;22(10):1361-6.
[3] Gupta S,Das G. Clinical and radiographic evaluation of zinc oxide eugenol and metapex in root canal treatment of primary teeth. J Indian Soc Pedod Prev Dent.2011 Jul-Sep;29(3):222-8.
| Storage | Store at -20°C |
| M.Wt | 164.2 |
| Cas No. | 97-53-0 |
| Formula | C10H12O2 |
| Solubility | insoluble in H2O; ≥59.2 mg/mL in DMSO; ≥62.2 mg/mL in EtOH |
| Chemical Name | 4-allyl-2-methoxyphenol |
| SDF | Download SDF |
| Canonical SMILES | COc(cc(CC=C)cc1)c1O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
