Ethambutol
Ethambutol is an antimycobacterial agent utilized particularly in microbiological and pharmacological investigations targeting mycobacterial infections. It functions by inhibiting arabinosyl transferases, enzymes involved prominently in the biosynthesis of arabinogalactan polymer, a core mycobacterial cell wall component. This inhibitory action disrupts the normal assembly of cell wall structures, resulting in a bacteriostatic effect against Mycobacterium species. In laboratory research, Ethambutol is frequently applied in studies involving mycobacterial cell wall biosynthesis mechanisms, susceptibility testing, and characterization of antimycobacterial resistance profiles. Reported IC50 values for its inhibitory effect on arabinosyl transferase activity typically range between 1 to 5 μg/mL depending on experimental conditions and mycobacterial strains utilized. Ethambutol can be used to establish animal models of hyperuricemia and optic neuropathy.
| Storage | Store at -20°C |
| M.Wt | 204.31 |
| Cas No. | 74-55-5 |
| Formula | C10H24N2O2 |
| Solubility | Soluble in DMSO |
| Chemical Name | (2S)-2-[2-[[(2S)-1-hydroxybutan-2-yl]amino]ethylamino]butan-1-ol |
| SDF | Download SDF |
| Canonical SMILES | CCC(CO)NCCNC(CC)CO |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Cell experiment [1]: | |
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Cell lines |
M.smegmatis, M.avium |
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Preparation method |
The solubility of this compound in DMSO is soluble. General tips for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months. |
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Reacting condition |
0.18mg/L, 15mg/L |
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Applications |
The MIC of ethambutol for M.smegmatis and M.avium is 0.18mg/L, 15mg/L respectively. |
| Animal experiment [1]: | |
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Animal models |
Mice infected with Mycobacterium tuberculosis and Mycobacterium avium |
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Dosage form |
100 mg/kg, gavage, once a week for 5 weeks |
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Application |
Ethambutol is effective in animal models. Compared to untreated, ethambutol-treated mice resulted in lower log CFU. |
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Other notes |
Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal. |
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References: [1]. Kaur D, Khuller GK. In vitro, ex-vivo and in vivo activities of ethambutol and sparfloxacin alone and in combination against mycobacteria. Int J Antimicrob Agents. 2001 Jan;17(1):51-5. PubMed PMID: 11137649. |
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Quality Control & MSDS
- View current batch:
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
