Estrone 3-sulfate (sodium salt)

Estrone 3-sulfate (sodium salt) (CAS No.: 438-67-5) is an endogenous estrogen ester with low intrinsic biological activity, but it can be converted by steroid sulfatase into the active estrone and estradiol. This conversion process can occur both in vivo and in vitro and plays an important role particularly in breast cancer-related research. As a substrate of the OATP1B3 transporter and an inhibitor of the OATP1B1 organic anion transporting polypeptide, this compound exhibits significant selectivity between OATP1B3 and OATP1B1, with IC50 values in the low micromolar range, reflecting its important regulatory capacity in cellular transport mechanisms. In animal experiments, Estrone 3-sulfate can promote the growth of N-nitroso-N-methylurea-induced mammary tumors in ovariectomized rats, providing a basis for studies of tumor biology mechanisms. This compound is widely used as a model ligand in exploring organic anion transporting polypeptides. In typical studies, Estrone 3-sulfate is used in various biological models, and its concentration is usually adjusted according to the specific experimental design and research objectives, thereby supporting drug discovery and development efforts.