ERK Inhibitor

ERK Inhibitor (CAS No.: 1049738-54-6) is a small-molecule modulator of the extracellular signal-regulated kinase (ERK) signaling pathway that exhibits preferential binding to the ERK2 isoform, with reported binding affinity in the low micromolar range. It functions by selectively inhibiting the phosphorylation of downstream ERK substrates, including Rsk-1 and Elk-1, thereby disrupting ERK-mediated signal transduction while exerting minimal influence on ERK phosphorylation by upstream kinases such as MEK1/2. This selective mechanism makes it a valuable tool for dissecting ERK-dependent cellular processes, including proliferation, differentiation, and survival, without broadly suppressing upstream pathway activation. As a research reagent, it is commonly utilized in biochemical and cell-based assays to investigate ERK pathway dynamics, validate target engagement, and support early-stage drug discovery efforts focused on mitogen-activated protein kinase signaling. Experimental concentrations typically fall within the micromolar range, although precise dosing conditions vary depending on the specific cellular context and study design.