Eliglustat hemitartrate

Eliglustat hemitartrate (CAS No.: 928659-70-5) is a synthetic small molecule commonly classified as a glycosphingolipid metabolism modulator and used in biomedical research as a potent and selective inhibitor of glucosylceramide synthase, the enzyme that catalyzes the first committed step in glycosphingolipid biosynthesis, thereby reducing cellular glucosylceramide production and influencing downstream sphingolipid network homeostasis, membrane lipid composition, and lysosomal substrate handling in mechanistic studies of sphingolipid biology; available reference data indicate inhibitory activity in the nanomolar range with an IC50 of 24 nM, and in research settings this profile supports its use as a tool compound for pathway interrogation, target validation, and phenotypic or mechanism informed screening workflows in relevant cell based systems and preclinical animal models, particularly where modulation of ceramide to glucosylceramide flux and related lysosomal stress responses are under investigation, while experimental concentrations or doses are selected according to specific study design, model context, and assay endpoints.