Elagolix Sodium
Catalog No.
C8704
Oral non-peptide GnRH receptor antagonist
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Elagolix is an oral non-peptide GnRH receptor antagonist used to treat endometriosis-associated pain, among others. It competitively binds to pituitary GnRH receptors, rapidly suppresses pulsatile GnRH signaling, and reduces LH and FSH secretion, leading to a dose-dependent decrease in ovarian estradiol and progesterone levels. Low doses produce partial estrogen suppression, while high doses can approach menopause-like levels, thereby relieving symptoms of estrogen-dependent diseases; meanwhile, depending on dose and treatment duration, there are hypoestrogenism-related adverse effects such as decreased bone mineral density.
| Storage | Store at -20°C |
| M.Wt | 653.58 |
| Cas No. | 832720-36-2 |
| Formula | C32H29F5N3NaO5 |
| Synonyms | NBI-56418 sodium |
| Chemical Name | sodium rac-(R)-4-((2-(5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl)-1-phenylethyl)amino)butanoate |
| SDF | Download SDF |
| Canonical SMILES | CC1=C(C2=C(C(OC)=CC=C2)F)C(N(C(N1CC3=C(C=CC=C3F)C(F)(F)F)=O)C[C@@H](C4=CC=CC=C4)NCCCC(O[Na])=O)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |