Elafibranor
Catalog No.
BA4428
An inhibitor.
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Elafibranor (GFT505) is a dual agonist of peroxisome proliferator-activated receptor (PPAR) α and δ, with in vitro agonist activities (EC50) of 45 nM and 175 nM for PPARα and PPARδ, respectively. By regulating PPARs-mediated lipid and energy metabolism signaling pathways, Elafibranor is widely used in studies on the pathological mechanisms and therapeutic research of primary biliary cholangitis (PBC) and related liver diseases, and can promote lipid homeostasis and improve disordered bile acid metabolism.
| Physical Appearance | A solid |
| Storage | -20°C |
| M.Wt | 384.49 |
| Cas No. | 923978-27-2 |
| Formula | C22H24O4S |
| Synonyms | GFT505 |
| Solubility | ≥52.3 mg/mL in DMSO; ≥10.16 mg/mL in EtOH with ultrasonic; insoluble in H2O |
| Chemical Name | (E)-2-(2,6-dimethyl-4-(3-(4-(methylthio)phenyl)-3-oxoprop-1-en-1-yl)phenoxy)-2-methylpropanoic acid |
| SDF | Download SDF |
| Canonical SMILES | O(C(C(O)=O)(C)C)C1=C(C)C=C(/C=C/C(=O)C2=CC=C(SC)C=C2)C=C1C |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |