Dracohodin perochlorate

Dracohodin perochlorate (CAS No.: 125536-25-6) is a naturally derived small molecule pigment associated with Dragon blood resin and is broadly categorized as a bioactive natural product for mechanistic pharmacology and phenotypic screening in inflammation, fibrosis, and oncology related research programs. In preclinical experimental systems, it has been reported to modulate key signaling networks including PI3K Akt and NF kappa B axes, influence TLR4 linked inflammatory regulation, increase p53 associated stress responses, promote caspase dependent apoptotic signaling, elevate intracellular reactive oxygen species, and induce G1 phase cell cycle arrest, collectively supporting its use as a probe for studying proliferation control, programmed cell death, and cellular stress adaptation. Available in vitro findings indicate activity is commonly observed in the micromolar domain, with some readouts varying by cell context and exposure duration, and published profiles further describe suppression of high glucose induced SGK1 and fibronectin expression in mesangial cell models, as well as growth inhibitory effects in fibroblast and multiple tumor cell paradigms. Accordingly, this compound is typically positioned as a research tool for pathway interrogation, target validation, and early stage hit to lead hypothesis generation in cell based assays and selected animal studies of tissue injury, inflammatory signaling, and metabolic stress biology, where concentrations or doses used in experiments typically depend on specific experimental designs and research objectives.