Doxazosin

Doxazosin (CAS No.: 74191-85-8) is a quinazoline derivative that, as a selective α?-adrenergic receptor antagonist, is widely used in the treatment of hypertension and benign prostatic hyperplasia. Its primary mechanism of action is to block postsynaptic α?-adrenergic receptors, leading to relaxation of vascular smooth muscle, thereby reducing peripheral vascular resistance and blood pressure. In addition, Doxazosin can relax smooth muscle in the prostate and bladder neck, improving urodynamics. In vitro studies show that Doxazosin effectively inhibits α?-adrenergic receptor activity in the nanomolar to low micromolar concentration range. Its use in cell and animal models typically involves evaluating its effects on vascular tone, prostatic smooth muscle relaxation, and related signaling pathways. The doses or concentrations used in experiments usually depend on the experimental design and research objectives.