DMBA

DMBA (CAS No. 57-97-6) is a polycyclic aromatic hydrocarbon compound mainly used to induce tumor formation in animal models. DMBA undergoes metabolic activation and forms covalent adducts with DNA, leading to gene mutations and malignant cellular transformation. The carcinogenic effects of DMBA involve multiple signaling pathways, including P450 enzyme-mediated metabolic activation and interference with DNA damage repair mechanisms. In cell models, DMBA can induce apoptosis and gene mutations, and is commonly used to study carcinogenic mechanisms and to screen anticancer drugs. In animal models, DMBA induces tumor formation via oral administration or subcutaneous injection, and is widely used in the establishment of breast cancer and skin cancer models. The dose or concentration used in experiments usually depends on the experimental design and research objectives.