DL-threo-PDMP (hydrochloride)

DL-threo-PDMP (hydrochloride) (CAS No.: 80938-69-8) is a synthetic sphingolipid metabolism modulator widely used as a biochemical tool in glycosphingolipid research and oncology-related studies. It functions primarily as a competitive inhibitor of glucosylceramide synthase, a key enzyme responsible for the conversion of ceramide to glucosylceramide, thereby regulating ceramide-mediated signaling pathways that influence cell proliferation, apoptosis, and stress responses. By disrupting glycosphingolipid biosynthesis, this compound has been shown in cellular and animal models to modulate drug resistance mechanisms, including restoring sensitivity to cisplatin in resistant tumor cell lines, highlighting its relevance in studies of chemoresistance. Additionally, DL-threo-PDMP (hydrochloride) exhibits activity against ring-stage Plasmodium falciparum parasites, supporting its use in parasitology research focused on lipid metabolism-dependent processes. Its inhibitory effects are typically observed at concentrations in the low micromolar range, although experimental conditions vary depending on the model system and study design. This compound is broadly applied in mechanistic studies of sphingolipid function, metabolic pathway interrogation, and early-stage drug discovery efforts targeting glycosphingolipid-associated pathways.