Dihomo-γ-Linolenoyl Ethanolamide

Dihomo-γ-Linolenoyl Ethanolamide (CAS No.: 150314-34-4) is an endogenous lipid mediator belonging to the endocannabinoid family, widely studied for its role in modulating cannabinoid receptor signaling and associated cellular processes. This compound functions as an agonist of cannabinoid CB1 and CB2 receptors, exhibiting activity in the nanomolar to low micromolar range, and is implicated in the regulation of intracellular signaling pathways linked to inflammation, neuronal communication, and metabolic homeostasis. Mechanistically, it can influence biological systems through modulation of receptor-mediated signal transduction and potential inhibition of enzyme activity involved in lipid signaling networks, thereby affecting diverse cellular responses. In experimental settings, Dihomo-γ-Linolenoyl Ethanolamide is utilized as a biochemical tool in neurobiology and metabolism-related research to investigate endocannabinoid system dynamics, receptor pharmacology, and lipid-mediated signaling pathways. Its application spans in vitro assays and in vivo models, where dosing and concentration parameters are adjusted according to specific study designs, supporting mechanistic exploration and target validation in early-stage drug discovery.