Digoxin
Digoxin effectively inhibits Na+/K+-ATPase and has the potential to treat arrhythmias and heart failure[1].
Digoxin treatment can reduce CHIKV infection of U-2 OS cells, primary human synovial fibroblasts (HSF), and Vero African green monkey kidney cells. Twenty-four hours after treatment with 1 μM digoxin, cell survival is only moderately compromised, which is 20 times the digoxin EC50 dose of the antiviral activity of CHIKV in these cells [1].
Reference:
[1]. Ashbrook A W, et al. Antagonism of the Sodium-Potassium ATPase Impairs Chikungunya Virus Infection. MBio, 2016, 7(3): e00693-16.
- 1. Qiushuang Sun, Huan Chen, Qianqian Lin. "Integrated pharmacokinetic properties and tissue distribution of Corydalis saxicola Bunting total alkaloids in HFHCD-induced mice: Implications for pharmacokinetic …." Biomedicine & Pharmacotherapy Volume 192, November 2025, 118665 PMID: 41124864
- 2. Zhang Y, Zheng D, et al. "Aberrant hydroxymethylation of ANGPTL4 is associated with selective intrauterine growth restriction in monochorionic twin pregnancies." Epigenetics. 2020;1-13 PMID: 32114885
| Physical Appearance | A solid |
| Storage | 4°C, protect from light |
| M.Wt | 780.94 |
| Cas No. | 20830-75-5 |
| Formula | C41H64O14 |
| Solubility | ≥33.25 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH |
| SDF | Download SDF |
| Canonical SMILES | C[C@H]1O[C@H](C[C@H](O)[C@@H]1O)O[C@H]2[C@@H](O)C[C@@H](O[C@@H]2C)O[C@H]3[C@@H](O)C[C@@H](O[C@@H]3C)O[C@H]4CC[C@@]5(C)[C@H](CC[C@@H]6[C@@H]5C[C@@H](O)[C@]7(C)[C@H](CC[C@]67O)C8=CC(=O)OC8)C4 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Cell experiment:[1] | |
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Cell lines |
Human osteosarcoma (U-2 OS) cells |
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Reaction Conditions |
0.01 ~ 10 μM digoxin for 1 h incubation |
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Applications |
Treatment of human cells with digoxin resulted in a dose-dependent decrease in infection by chikungunya virus (CHIKV). Inhibition by digoxin was cell type-specific, as digoxin treatment of either murine or mosquito cells did not diminish CHIKV infection. |
| Animal experiment:[2] | |
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Animal models |
Female mongrel dogs in which the main pulmonary artery had been constricted progressively until cardiac failure developed |
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Dosage form |
1 ~ 1.2 mg Administered intravenously |
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Applications |
Acute digoxin treatment decreased right atrial pressure and increased cardiac output in a canine model of congestive heart failure produced by pulmonary artery constriction |
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Note |
The technical data provided above is for reference only. |
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References: 1. Ashbrook AW, Lentscher AJ, Zamora PF, et al. Antagonism of the Sodium-Potassium ATPase Impairs Chikungunya Virus Infection. mBio, 2016, 7(3): e00693-16. 2. Davis JO, Howell DS, Hyatt RE. Effects of acute and chronic digoxin administration in dogs with right-sided congestive heart failure produced by pulmonary artery constriction. Circulation Research. 1955, 3(3): 259-263. |
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Quality Control & MSDS
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