Diethylmaleate
Diethylmaleate (CAS: 141-05-9) is a small-molecule compound that depletes intracellular glutathione (GSH), modulating cellular redox-sensitive pathways. Diethylmaleate exerts its biological activity primarily through induction of oxidative stress and ROS generation, leading to modulation of cell cycle, apoptosis, gene expression, and activation of MAPK signaling pathways. In vitro studies demonstrate that Diethylmaleate-mediated GSH depletion triggers cell cycle arrest and apoptosis. According to animal-based research, diethylmaleate demonstrates effects on reproductive systems, including altered antioxidant status of testis and sperm. Diethylmaleate holds research potential in studies of oxidative stress, redox regulation, and toxicology.
References:
[1] Priya S,Nigam A,Bajpai P,Kumar S. Diethyl maleate inhibits MCA+TPA transformed cell growth via modulation of GSH, MAPK, and cancer pathways. Chem Biol Interact.2014 Aug 5;219:37-47.
[2] Kaur P,Kalia S,Bansal MP. Effect of diethyl maleate induced oxidative stress on male reproductive activity in mice: redox active enzymes and transcription factors expression. Mol Cell Biochem.2006 Oct;291(1-2):55-61.
| Storage | Store at -20°C |
| M.Wt | 172.18 |
| Cas No. | 141-05-9 |
| Formula | C8H12O4 |
| Solubility | insoluble in H2O; ≥51 mg/mL in DMSO; ≥62.1 mg/mL in EtOH |
| Chemical Name | diethyl maleate |
| SDF | Download SDF |
| Canonical SMILES | CCOC(/C=C\C(OCC)=O)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
