Deoxynojirimycin Tetrabenzyl Ether

Deoxynojirimycin Tetrabenzyl Ether (CAS No.: 69567-11-9) is a synthetic derivative of the iminosugar deoxynojirimycin and is primarily utilized in biochemical and pharmacological research as a butyrylcholinesterase (BuChE) inhibitor and as a synthetic intermediate in glycosphingolipid metabolism studies. It exhibits inhibitory activity against human BuChE through interaction with the enzyme’s active site, with potency in the low micromolar range, making it a useful tool for probing cholinesterase-mediated pathways relevant to neuroendocrine regulation, drug metabolism, and neurodegenerative disorders such as Alzheimer’s disease. In addition to its cholinesterase inhibitory profile, this compound serves as a key intermediate in the preparation of glucosylceramide synthase inhibitors, linking it to pathways involved in glycosphingolipid biosynthesis and lysosomal storage disorders, and indirectly to modulation of α-glucosidase I and II through derivative compounds. As such, it is broadly applied in enzyme mechanism studies, early-stage drug discovery, and target validation assays, with experimental concentrations typically optimized according to specific cellular or biochemical assay conditions.