DBCO-Val-Cit-PABC-PNP
DBCO-Val-Cit-PABC-PNP (CAS 2994332-18-0) is a core cleavable linker for ADC (Antibody-Drug Conjugate) development, designed for precise targeted drug delivery. Mechanistically, the DBCO group enables efficient copper-free click conjugation with azide-containing biomolecules. After the ADC is internalized by tumor cells, cathepsin B in the lysosome specifically cleaves the Val-Cit dipeptide sequence. Subsequently, the PABC group undergoes self-immolative dissociation to release the drug payload. Main application scenarios include the construction of tumor-targeted ADCs, bioorthogonal labeling and in vivo imaging, and modification of nanodrug delivery systems. Additionally, the optimized C4 spacer arm enhances biocompatibility and plasma stability, providing a safe and efficient molecular tool for precision medicine.
| Storage | -20°C，stored under nitrogen, away from moisture and light |
| M.Wt | 859.92 |
| Cas No. | 2994332-18-0 |
| Formula | C46H49N7O10 |
| SDF | Download SDF |
| Canonical SMILES | NC(NCCC[C@@H](C(NC1=CC=C(COC(OC2=CC=C([N+]([O-])=O)C=C2)=O)C=C1)=O)NC([C@H](C(C)C)NC(CCCCC(N3CC(C=CC=C4)=C4C#CC5=C3C=CC=C5)=O)=O)=O)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
