D-+-Galactosamine hydrochloride
D-+-Galactosamine hydrochloride (CAS 1772-03-8) is a water-soluble amino sugar derivative, functioning as a hepatotoxic agent in mammalian liver cells and exhibiting selective toxicity in hepatocytes. Additionally, it serves as a metabolic inhibitor by interfering with the synthesis of RNA and proteins in hepatic tissues.
In experimental studies, D-+-Galactosamine hydrochloride induces cellular injury and apoptosis with observable dose-dependent cytotoxic effects, tested against various primary hepatocyte cultures and animal models. It can also prompt the depletion of uridine nucleotides and sensitize cells to inflammatory mediators such as endotoxins, thereby enhancing the susceptibility of hepatocytes to cytokine-induced damage.
In biomedical research applications, D-+-Galactosamine hydrochloride is widely used for the induction of experimental liver injury and acute hepatitis in animal models to study hepatocellular responses, inflammation, and drug efficacy in preclinical evaluations.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 215.63 |
| Cas No. | 1772-03-8 |
| Formula | C6H13NO5+adduct |
| Synonyms | D-+-Galactosamine |
| Solubility | ≥21.6 mg/mL in H2O; insoluble in EtOH; insoluble in DMSO |
| Chemical Name | (2R,3R,4R,5R)-2-amino-3,4,5,6-tetrahydroxyhexanal hydrochloride |
| SDF | Download SDF |
| Canonical SMILES | N[C@H]([C@H]([C@H]([C@@H](CO)O)O)O)C=O.Cl |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
