Cyclopiazonic acid is a neurotoxic secondary metabolite produced by A. flavus and is a nanomolar inhibitor of endoplasmic reticulum calcium ATPase (Ca2+ATPase; SERCA). Cyclobenzoic acid does not inhibit many other types of membrane-bound ATPase, it can effectively inhibit SERCA in intact tissues, smooth muscle and endothelium, and isolated cells[1,2]. It is an effective inducer of plant cell death[3].
References:
[1]. Mumtaz S, Burdyga G, Borisova L, et al. The mechanism of agonist induced Ca2+ signalling in intact endothelial cells studied confocally in in situ arteries. Cell Calcium, 2011, 49(1): 66-77.
[2]. Berra-Romani R, Raqeeb A, Torres-Jácome J, et al. The mechanism of injury-induced intracellular calcium concentration oscillations in the endothelium of excised rat aorta. Journal of Vascular Research, 2012, 49(1): 65-76.
[3]. Chalivendra S C, et al. Cyclopiazonic Acid Is a Pathogenicity Factor for Aspergillus flavus and a Promising Target for Screening Germplasm for Ear Rot Resistance. Mol Plant Microbe Interact, 2017, 30(5): 361-373.