CNQX
CNQX (CAS 115066-14-3) is an active quinoxaline derivative compound, functioning as a competitive antagonist at AMPA and kainate receptors in the central nervous system, and exhibiting inhibitory activity at non-NMDA glutamate receptors. Additionally, it acts by selectively blocking excitatory synaptic transmission mediated by these ionotropic glutamate receptors without significant interaction with NMDA receptors.
In experimental conditions, CNQX effectively inhibits receptor-mediated currents with an IC50 of 0.3 μM for AMPA receptors and 1.5 μM for kainate receptors, tested against neuronal cell preparations. It can also suppress excitatory postsynaptic potentials and reduce neural hyperexcitability linked to glutamatergic signaling.
In pharmacological and neuroscience research, CNQX is widely used for the study of glutamatergic neurotransmission, allowing precise dissection of AMPA and kainate receptor functions in vitro and in vivo. Its efficacy in blocking AMPA/kainate receptor activity makes it valuable for evaluating synaptic mechanisms, understanding neural circuit dynamics, and investigating the molecular underpinnings of excitotoxicity and related neuropathological processes.
- 1. Ziting Zhou, Bing Dong, et al. "GLS1-Mediated Redundancy in Glutamate Accelerates Arterial Calcification via Activating NMDAR/Ca2+/β-Catenin Pathway." Adv Sci (Weinh). 2025 Jun;12(21):e2414252 PMID: 40289670
- 2. Binglu Ye, Yawei Yuan, et al. "Restoring Wnt signaling in a hormone-simulated postpartum depression model remediated imbalanced neurotransmission and depressive-like behaviors." Mol Med. 2023 Jul 25;29(1):101. PMID: 37491227
- 3. Qiu Y, Zheng F, et al. "Angiotensin Type 1 Receptors and Superoxide Anion Production in Hypothalamic Paraventricular Nucleus Contribute to Capsaicin-Induced Excitatory Renal Reflex and Sympathetic Activation." Neurosci Bull. 2020;10.1007/s12264-019-00460-y. PMID:31989424
| Physical Appearance | A solid |
| Storage | Store at RT |
| M.Wt | 232.16 |
| Cas No. | 115066-14-3 |
| Formula | C9H4N4O4 |
| Synonyms | 6-cyano-7-nitroquinoxaline-2,3-dione; FG9065 |
| Solubility | ≥23.2 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O |
| Chemical Name | 7-nitro-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-carbonitrile |
| SDF | Download SDF |
| Canonical SMILES | O=C1NC2=CC([N+]([O-])=O)=C(C#N)C=C2NC1=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
Related Biological Data
