CNQX
CNQX is a potent and competitive antagonist for AMPA/kainate receptors.
Superfusion of hippocampal slices and CNQX (2-5 μM) reversibly blocks Schaffer collaterals and mossy fiber excitatory post-synaptic potentials (EPSP), and also retains fast and slow GABA-mediated inhibitory effects[1].
Ten minutes before the test, CNQX (0.5 or 1.25 μg) is bilaterally infused into the amygdala or dorsal hippocampus, which partially prevented the expression of hypotensive avoidance in rats at 24 h after training. At a dose of 0.5 μg, CNQX causes complete blockade[2].
References:
[1]. Neuman R S, Ben-Ari Y, Gho M, et al. Blockade of excitatory synaptic transmission by 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) in the hippocampus in vitro. Neuroscience Letters, 1988, 92(1): 64-68.
[2]. Kim M, Campeau S, Falls W A, et al. Infusion of the non-NMDA receptor antagonist CNQX into the amygdala blocks the expression of fear-potentiated startle. Behav Neural Biol, 1993, 59(1): 5-8.
- 1. Binglu Ye, Yawei Yuan, et al. "Restoring Wnt signaling in a hormone-simulated postpartum depression model remediated imbalanced neurotransmission and depressive-like behaviors." Mol Med. 2023 Jul 25;29(1):101. PMID: 37491227
- 2. Qiu Y, Zheng F, et al. "Angiotensin Type 1 Receptors and Superoxide Anion Production in Hypothalamic Paraventricular Nucleus Contribute to Capsaicin-Induced Excitatory Renal Reflex and Sympathetic Activation." Neurosci Bull. 2020;10.1007/s12264-019-00460-y. PMID:31989424
| Physical Appearance | A solid |
| Storage | Store at RT |
| M.Wt | 232.16 |
| Cas No. | 115066-14-3 |
| Formula | C9H4N4O4 |
| Solubility | ≥23.2 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O |
| Chemical Name | 7-nitro-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-carbonitrile |
| SDF | Download SDF |
| Canonical SMILES | O=C1NC2=CC([N+]([O-])=O)=C(C#N)C=C2NC1=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
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