Clozapine N-oxide(CNO) dihydrochloride
Catalog No.
B8466
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Clozapine N-oxide (CNO) dihydrochloride (CAS 2250025-93-3) is a synthetic metabolite derived from clozapine, commonly utilized as an agonist for designer receptors exclusively activated by designer drugs (DREADDs). In neuroscience research, CNO selectively binds and activates engineered muscarinic receptors, particularly hM3Dq and hM4Di, thereby influencing neuronal signaling upon penetrating the blood-brain barrier. Due to its specificity, CNO dihydrochloride serves as a valuable tool for dissecting neuronal circuits and elucidating their functional roles in behavioral studies.
| Storage | Store at -20°C |
| M.Wt | 415.74 |
| Cas No. | 2250025-93-3 |
| Formula | C18H21Cl3N4O |
| Solubility | Soluble in DMSO |
| Chemical Name | 4-(8-chloro-10H-dibenzo[b,e][1,4]diazepin-11-yl)-1-methylpiperazine 1-oxide dihydrochloride |
| SDF | Download SDF |
| Canonical SMILES | [O-][N+]1(C)CCN(C2=C(C=CC=C3)C3=NC(C=CC(Cl)=C4)=C4N2)CC1.Cl.Cl |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
- View current batch:
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
