Cloperastine hydrochloride

Cloperastine hydrochloride (CAS No.: 14984-68-0) is a synthetic small molecule widely used as a pharmacological research reagent in neuropharmacology and ion channel safety studies, functionally characterized by centrally acting antitussive and antihistaminic profiles and classified in discovery programs as a bioactive reference compound for off target liability evaluation rather than as a biologically derived natural product, with reported concentration dependent inhibition of hERG potassium current as a key experimentally observed mechanism and in vitro potency in the nanomolar range alongside broader receptor level activities that support investigation of histaminergic and cough related signaling networks in preclinical systems; within biomedical research workflows it is commonly applied to mechanistic cell based assays, electrophysiology platforms, and comparative compound screening panels to map target engagement and safety relevant phenotypes, and in translationally oriented nonclinical studies it may also be incorporated into animal model experiments for pharmacodynamic benchmarking, while the concentrations or doses used in experiments typically depend on specific experimental designs and research objectives.