CHMFL-EGFR-202
Catalog No.
BA6389
CHMFL-EGFR-202 is a potent, irreversible inhibitor of the epidermal growth factor receptor mutant kinase.
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CHMFL-EGFR-202 is a potent and irreversible inhibitor of mutant kinases of the epidermal growth factor receptor, with values of 5.3 nM and 8.3 nM for the drug-resistant mutant T790M and WT kinases, respectively.In cells, CHMFL-EGFR-202 is 10-fold more selective for L858R/T790M than the wild type.CHMFL-EGFR-202 covalently binds in the "DFG-in-C-helix-out" inactive binding conformation to mutant-driven non-small cell lung cancer (NSCLC). CHMFL-EGFR-202 covalently binds in an inactive "DFG-in-C-helix-out" binding conformation and has a strong antiproliferative effect on mutant-driven non-small cell lung cancer (NSCLC) cell lines.
| Physical Appearance | A solid |
| Storage | -20°C, protect from light |
| M.Wt | 489.96 |
| Cas No. | 2089381-40-6 |
| Formula | C25H24ClN7O2 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |