Chlorodicyclohexylphosphine

Dicyclohexylchlorophosphine is a typical moisture-sensitive, air-sensitive, strongly corrosive P–Cl reagent that readily undergoes exothermic hydrolysis or chlorination with water, alcohols, and amines. It is used to synthesize dicyclohexylphosphine/phosphine oxide, phosphine ligands, and phosphorylating intermediates, and is commonly found in the preparation of catalytic ligands, pharmaceuticals, and material precursors. In the literature, it is mostly used under anhydrous inert atmosphere in dry solvents such as THF/THF‑hexane/DCM, with a substrate concentration of about 0.05–0.5 M, stirred at 0–25 ℃ for 1–24 h, charged at 1.0–1.5 equivalents, and used together with an organic base to scavenge acid.