Chenodeoxycholic acid24-Acy-β-D-glucuronide

Chenodeoxycholic acid 24-acyl-β-D-glucuronide is a metabolite of the primary bile acid chenodeoxycholic acid (CDCA), which is catalyzed by uridine diphosphate glucuronosyltransferase (UGT) in the liver or intestinal mucosa. As the main binding metabolite of CDCA in the body, Chenodeoxycholic acid 24-acyl-β-D-glucuronide can reduce the cytotoxicity of free bile acids and participate in the regulation of gut-hepatic circulation of bile acids. Studies have shown that its production may abnormally increase in cholestatic diseases (such as primary sclerosing cholangitis), reflecting disorders in liver detoxification function or bile acid metabolism. As an endogenous metabolic marker, its level changes can be used to analyze the role of bile acid binding metabolic pathways in liver and gallbladder diseases, and also provide potential targets for the development of drugs targeting bile acid metabolism.