Chenodeoxycholic acid-3-β-D-glucuronide

Chenodeoxycholic acid (3-glucuronide) is a phase II metabolite formed in the body by deoxycholic acid (CDCA) catalyzed by glucuronosyltransferase. As an endogenous bile acid metabolite, it can efficiently activate the key nuclear receptor fanitol X receptor (FXR). The half-maximal effect concentration (EC??) for activating FXR in HEK293T cells is 11 μM. In vitro experiments show that its EC?? is approximately 8 μM, indicating a strong affinity for FXR. This metabolite regulates the expression of target genes (such as BSEP, SHP, etc.) by binding to FXR, participates in the negative feedback regulation of bile acid synthesis and the maintenance of liver and intestinal circulation homeostasis.