CFT8634
CFT8634 (CAS No.: 2704617-96-7) is an orally bioavailable, heterobifunctional proteolysis-targeting chimera (PROTAC) designed as a selective degrader of bromodomain-containing protein 9 (BRD9), functioning through recruitment of the cereblon (CRBN) E3 ubiquitin ligase complex to induce targeted ubiquitination and subsequent proteasomal degradation of BRD9. By promoting ternary complex formation between BRD9 and CRBN, CFT8634 effectively reduces BRD9 protein levels and modulates downstream chromatin remodeling and transcriptional programs associated with oncogenic signaling pathways. This compound has demonstrated the ability to inhibit the proliferation of BRD9-dependent and SMARCB1-deficient cancer cell lines, including models of synovial sarcoma and malignant rhabdoid tumors, with activity typically observed in the nanomolar to low micromolar range in biochemical and cellular assays. CFT8634 serves as a valuable chemical probe for investigating BRD9 biology, epigenetic regulation, and synthetic lethal interactions in SWI/SNF complex-deficient systems, and is widely applied in mechanistic studies, target validation, and degrader-based drug discovery workflows. Experimental concentrations and treatment regimens vary depending on assay format, cell type, and study objectives.
| Physical Appearance | Solid |
| Storage | -20°C |
| M.Wt | 710.80 |
| Cas No. | 2704617-96-7 |
| Formula | C37H45F3N6O5 |
| Solubility | ≥44 mg/mL in DMSO; ≥41 mg/mL in EtOH; insoluble in H2O |
| Chemical Name | (S)-3-((4-(4-((S)-1-(2,6-dimethoxy-4-(1,4,5-trimethyl-6-oxo-1,6-dihydropyridin-3-yl)benzyl)-3,3-difluoropiperidin-4-yl)piperazin-1-yl)-3-fluorophenyl)amino)piperidine-2,6-dione |
| Canonical SMILES | CC1=C(C)C(N(C)C=C1C2=CC(OC)=C(CN3CC[C@H](N4CCN(C5=C(F)C=C(N[C@@H]6C(NC(CC6)=O)=O)C=C5)CC4)C(F)(F)C3)C(OC)=C2)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |