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In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Cell lines
HEK293 cell
Preparation method
The solubility of this compound in H2O is ≥8.7 mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.
Reacting condition
1mM
Applications
HEK293 cells absorbed Cephalexin, showing saturation kinetics, K (m) = 5.9 mM, and the maximum absorption value at pH 7.0 in the bell-shaped pH profile.
Animal models
Mate1(-/-) mice
Dosage form
5mg/kg, intragastrical administration
Application
After Cephalexin treatment, the plasma concentration of Mate1 (-/-) mutant mice was reduced compared to the control group.
Other notes
Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.
References:
[1]. Watanabe S, Tsuda M, Terada T, Katsura T, Inui K. Reduced renal clearance of a zwitterionic substrate cephalexin in MATE1-deficient mice. J Pharmacol Exp Ther. 2010 Aug;334(2):651-6. doi: 10.1124/jpet.110.169433. Epub 2010 May 19. PubMed PMID: 20484555.