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Cephalexin

Catalog No.
B1692
Antibiotic
Grouped product items
SizePriceStock Qty
10mM (in 1mL H2O)
$50.00
In stock
1g
$52.00
In stock
5g
$90.00
In stock

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Email: [email protected]

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Background

Cefalexin is a cephalosporin antibiotic.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt347.39
Cas No.15686-71-2
FormulaC16H17N3O4S
Solubilityinsoluble in DMSO; insoluble in EtOH; ≥8.7 mg/mL in H2O
Chemical Name(6R,7R)-7-[[(2R)-2-amino-2-phenylacetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
SDFDownload SDF
Canonical SMILESCC1=C(N2C(C(C2=O)NC(=O)C(C3=CC=CC=C3)N)SC1)C(=O)O
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Protocol

Cell experiment [1]:

Cell lines

HEK293 cell

Preparation method

The solubility of this compound in H2O is ≥8.7 mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.

Reacting condition

1mM

Applications

HEK293 cells absorbed Cephalexin, showing saturation kinetics, K (m) = 5.9 mM, and the maximum absorption value at pH 7.0 in the bell-shaped pH profile.

Animal experiment [1]:

Animal models

Mate1(-/-) mice

Dosage form

5mg/kg, intragastrical administration

Application

After Cephalexin treatment, the plasma concentration of Mate1 (-/-) mutant mice was reduced compared to the control group.

Other notes

Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.

References:

[1]. Watanabe S, Tsuda M, Terada T, Katsura T, Inui K. Reduced renal clearance of a zwitterionic substrate cephalexin in MATE1-deficient mice. J Pharmacol Exp Ther. 2010 Aug;334(2):651-6. doi: 10.1124/jpet.110.169433. Epub 2010 May 19. PubMed PMID: 20484555.

Quality Control

Chemical structure

Cephalexin