Ceftazidime pentahydrate

Ceftazidime pentahydrate (CAS No.: 78439-06-2) is a third-generation cephalosporin antibiotic widely utilized in biomedical research for its broad-spectrum activity against Gram-positive and Gram-negative aerobic bacteria. It exerts its antibacterial effects by binding to penicillin-binding proteins, thereby inhibiting the final stages of bacterial cell wall synthesis and leading to cell lysis. Notably, it demonstrates strong activity against members of the Enterobacteriaceae family, including β-lactamase-producing strains, due to its resistance to hydrolysis by many β-lactamases. In vitro studies have shown potent antibacterial activity across a range of clinically relevant species, with efficacy typically observed in the low micromolar to sub-micromolar range depending on the organism and assay conditions. Ceftazidime pentahydrate is frequently employed in cell-based assays and animal infection models to investigate antimicrobial resistance mechanisms, evaluate β-lactamase inhibition strategies, and assess combination therapies targeting multidrug-resistant pathogens. Experimental concentrations or dosing regimens vary according to specific study designs and microbial susceptibility profiles, making it a valuable reference compound in antibacterial drug discovery and translational research.