Carperitide Acetate

Carperitide Acetate (CAS No.: 1366000-58-9) is a synthetic acetate form of the 28 amino acid atrial natriuretic peptide sequence corresponding to human and porcine ANP 1 to 28 and is broadly categorized as a cardio renal endocrine peptide tool compound for cardiovascular and renal pharmacology research in biomedical discovery settings, with biological relevance derived from the endogenous atrial hormone released by cardiomyocytes in response to mechanical stretch and cardiac stress and with primary mechanistic activity as an agonistic ligand of natriuretic peptide receptor A that stimulates receptor linked guanylyl cyclase signaling to elevate intracellular cyclic guanosine monophosphate and downstream protein kinase G associated responses, while also showing functional suppression of endothelin 1 secretion under angiotensin II stimulated conditions and broader modulatory effects on renin angiotensin aldosterone system related signaling in experimental systems; in vitro pharmacology is commonly characterized through receptor activation and second messenger readouts and is generally assessed across nanomolar to micromolar concentration ranges depending on assay format, cell background, and endpoint selection, and this molecule is therefore used as a pathway directed reference peptide in studies of vascular tone regulation, sodium handling biology, endothelial and smooth muscle signaling, cardiac stress response biology, and mechanism based drug screening workflows, including cell based assays and preclinical animal model investigations where the concentrations or doses used in experiments typically depend on specific experimental designs and research objectives.