Buspirone
Catalog No.
BA5024
Buspirone is an orally active receptor agonist and dopamine D2 autoreceptor antagonist.
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Buspirone (CAS No.: 36505-84-7) is an orally active anxiolytic, primarily acting as a partial agonist of the 5-hydroxytryptamine 1A (5-HT1A) receptor, while also exhibiting antagonistic activity at the dopamine D2 receptor. Its unique mechanism of action has attracted considerable attention in research on neuropsychiatric disorders such as anxiety and depression. In in vitro studies, Buspirone shows affinity for the 5-HT1A receptor in the nanomolar to low micromolar range, with specific values varying depending on experimental conditions. In cell and animal models, Buspirone is commonly used to evaluate its effects on neurotransmitter release, receptor signaling, and behavior. The doses or concentrations used in experiments typically depend on the experimental design and research objectives. In addition, Buspirone is also used as a reference compound in drug screening studies to assess the potential efficacy of novel anxiolytic agents.
| Physical Appearance | A solid |
| Storage | -20°C |
| M.Wt | 385.50 |
| Cas No. | 36505-84-7 |
| Formula | C21H31N5O2 |
| Solubility | ≥12.35 mg/mL in DMSO with ultrasonic; ≥9.78 mg/mL in EtOH with ultrasonic; insoluble in H2O |
| Chemical Name | 8-(4-(4-(pyrimidin-2-yl)piperazin-1-yl)butyl)-8-azaspiro[4.5]decane-7,9-dione |
| Canonical SMILES | O=C1N(C(=O)CC2(C1)CCCC2)CCCCN3CCN(C4=NC=CC=N4)CC3 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
