BRD32048

BRD32048 (CAS No.: 433694-46-3) is a small-molecule chemical probe that directly targets the oncogenic transcription factor ETS variant 1 (ETV1), a regulator frequently dysregulated in cancers through chromosomal rearrangements, amplification, or lineage-specific expression. Acting as a direct ETV1 binder with a dissociation constant in the low micromolar range (approximately 17.1 μM), BRD32048 suppresses ETV1 transcriptional activity by interfering with p300-mediated acetylation, a post-translational modification that normally enhances ETV1 protein stability and function. Inhibition of this acetylation promotes proteasomal degradation of ETV1, thereby attenuating downstream gene expression programs associated with tumor progression. Functionally, BRD32048 has been shown to impair the invasive capacity of ETV1-dependent cancer cells in vitro in a dose-dependent manner at micromolar concentrations, supporting its utility as a perturbagen for dissecting ETV1-driven signaling pathways and transcriptional networks. This compound is widely applied in cellular models to investigate transcription factor regulation, oncogenic signaling, and epigenetic modulation, with experimental concentrations typically optimized according to specific assay conditions and research objectives.