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BMS-927711

Catalog No.
A3259
CGRP receptor antagonist
Grouped product items
SizePriceStock Qty
5mg
$120.00
In stock
10mg
$180.00
In stock
25mg
$370.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

BMS-927711 (CAS: 1289023-67-1) is an orally bioavailable antagonist targeting the calcitonin gene-related peptide (CGRP) receptor. CGRP acts through a G-protein coupled receptor composed of calcitonin receptor-like receptor (CLR), receptor activity-modifying protein 1 (RAMP1), and receptor component protein (RCP). Research shows that CGRP levels are elevated during migraine episodes, suggesting a role in migraine pathogenesis. In binding assays using SK-N-MC cell membranes expressing endogenous human CGRP receptors, BMS-927711 exhibited potent CGRP receptor antagonism (IC50 = 0.14 nM). Clinical studies have demonstrated its potential application in the acute treatment of migraine.

Product Citation

Chemical Properties

StorageStore at -20°C
M.Wt534.56
Cas No.1289023-67-1
FormulaC28H28F2N6O3
SynonymsBMS 927711;BMS927711
Solubility≥46.7 mg/mL in DMSO; ≥5.63 mg/mL in EtOH with ultrasonic; insoluble in H2O
Chemical Name5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate
SDFDownload SDF
Canonical SMILESFC1=CC=CC(C2C(N)C(C=CC=N3)=C3C(OC(N4CCC(N5C6=C(N=CC=C6)NC5=O)CC4)=O)CC2)=C1F
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control