BMS-927711
Catalog No.
A3259
CGRP receptor antagonist
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BMS-927711 (CAS: 1289023-67-1) is an orally bioavailable antagonist targeting the calcitonin gene-related peptide (CGRP) receptor. CGRP acts through a G-protein coupled receptor composed of calcitonin receptor-like receptor (CLR), receptor activity-modifying protein 1 (RAMP1), and receptor component protein (RCP). Research shows that CGRP levels are elevated during migraine episodes, suggesting a role in migraine pathogenesis. In binding assays using SK-N-MC cell membranes expressing endogenous human CGRP receptors, BMS-927711 exhibited potent CGRP receptor antagonism (IC50 = 0.14 nM). Clinical studies have demonstrated its potential application in the acute treatment of migraine.
| Storage | Store at -20°C |
| M.Wt | 534.56 |
| Cas No. | 1289023-67-1 |
| Formula | C28H28F2N6O3 |
| Synonyms | BMS 927711;BMS927711 |
| Solubility | ≥46.7 mg/mL in DMSO; ≥5.63 mg/mL in EtOH with ultrasonic; insoluble in H2O |
| Chemical Name | 5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate |
| SDF | Download SDF |
| Canonical SMILES | FC1=CC=CC(C2C(N)C(C=CC=N3)=C3C(OC(N4CCC(N5C6=C(N=CC=C6)NC5=O)CC4)=O)CC2)=C1F |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
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