BI-2865
Catalog No.
BA5760
BI-2865 is a non-covalent pan-inhibitor.
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BI-2865 is a non-covalent pan-inhibitor.BI-2865 binds to KRASWT, G12C, G12D, G12V, and G13D mutants at 6.9, 4.5, 32, 26, and 4.3 nM, respectively.BI-2865 inhibits the proliferation of BaF3 cells expressing the KRASG12C, G12D, or G12V mutants (mean IC : approximately 140 nM).
| Physical Appearance | A solid |
| Storage | -20°C |
| M.Wt | 465.57 |
| Cas No. | 2937327-93-8 |
| Formula | C23H27N7O2S |
| Solubility | ≥57.6 mg/mL in DMSO; ≥53.7 mg/mL in EtOH; insoluble in H2O |
| Chemical Name | (S)-2-amino-4-methyl-4-(3-(4-((S)-1-((S)-1-methylpyrrolidin-2-yl)ethoxy)pyrimidin-2-yl)-1,2,4-oxadiazol-5-yl)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile |
| SDF | Download SDF |
| Canonical SMILES | NC(S1)=C(C#N)C2=C1CCC[C@@]2(C3=NC(C4=NC(O[C@@H](C)[C@@H]5CCCN5C)=CC=N4)=NO3)C |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
