BI-2852
Catalog No.
BA5763
BI-2852 is an inhibitor of the switchSI/II pocket with nanomolar affinity through structure-based design of the active molecule.
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BI-2852 is an inhibitor of the switchSI/II pocket with nanomolar affinity through structure-based design of the active molecule.BI-2852 is mechanistically distinct from covalent KRAS inhibitors (binds switchII) and binds 10-fold more strongly to active KRAS than to KRAS (740 nM vs. 7.5 μM ).BI-2852 blocks the interaction of GEF, GAP and effectors with KRAS, leading to inhibition of downstream signaling and antiproliferative effects in KRAS mutant cells.
| Physical Appearance | A solid |
| Storage | 4°C |
| M.Wt | 516.59 |
| Cas No. | 2375482-51-0 |
| Formula | C31H28N6O2 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |