BFH772
Catalog No.
B6199
VEGFR2 inhibitor
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BFH772 (CAS 890128-81-1) is a small-molecule inhibitor targeting VEGFR2 kinase, exhibiting an IC50 value of 3 nM. It selectively inhibits signaling mediated via VEGFR2, a receptor tyrosine kinase activated by VEGFs (VEGF-A, VEGF-B, VEGF-C, VEGF-D) and PlGF, crucial in angiogenesis. BFH772 displays approximately 500-fold reduced potency against related receptors FLK-1, FLT-1, and FLT-4 and about 40-fold lower efficacy against kinases such as B-RAF, RET, and TIE-2. In animal tumor models, oral administration markedly reduces tumor growth and angiogenesis. BFH772 has entered clinical studies for rosacea treatment.
| Storage | Store at -20°C |
| M.Wt | 439.39 |
| Cas No. | 890128-81-1 |
| Formula | C23H16F3N3O3 |
| Solubility | ≥53.4 mg/mL in DMSO; ≥15.33 mg/mL in EtOH; insoluble in H2O |
| Chemical Name | 6-((6-(hydroxymethyl)pyrimidin-4-yl)oxy)-N-(3-(trifluoromethyl)phenyl)-1-naphthamide |
| SDF | Download SDF |
| Canonical SMILES | O=C(C1=C2C=CC(OC3=NC=NC(CO)=C3)=CC2=CC=C1)NC4=CC=CC(C(F)(F)F)=C4 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
