Berberrubine chloride

Berberrubine chloride (CAS 15401-69-1) is an orally bioavailable isoquinoline alkaloid, functioning as a metabolite of berberine in mammalian systems and exhibiting modulatory activity in gastrointestinal tissues and immune-related targets. Additionally, it demonstrates anti-inflammatory effects through regulation of inflammatory mediators.

In preclinical experimental contexts, Berberrubine reduces the severity of colitis symptoms in animal models, with efficacy observed in chemically-induced ulcerative colitis. Cellular and molecular assays have shown that it can inhibit the expression of key pro-inflammatory cytokines in colon tissue and suppress markers of oxidative stress, though precise values (e.g., IC50) remain to be fully elucidated in current datasets. It can also regulate other inflammatory pathways and modulate the infiltration of immune cells within affected tissues.

In pharmaceutical and biomedical research, Berberrubine chloride is widely used for investigating the mechanisms underlying gastrointestinal inflammation, its potential therapeutic effects in inflammatory bowel disease models, and its value in studying metabolic transformation of isoquinoline alkaloids. As an active metabolite, Berberrubine serves as a useful tool for elucidating the pharmacodynamic and pharmacokinetic profiles of related natural compounds, and it provides a promising basis for the development of anti-inflammatory agents targeting colonic and systemic inflammatory disorders.