Berberine hydrochloride
Berberine hydrochloride (CAS: 633-65-8) is a natural isoquinoline alkaloid derived from Berberis species. Berberine hydrochloride has been traditionally used as an antidiarrheal agent because of its antibacterial activity against Escherichia coli and Shigella spp. In addition, berberine hydrochloride interacts with various mammalian proteins involved in the regulation of metabolism and apoptosis. In metabolic regulation, berberine hydrochloride activates AMPK, leading to downstream effects on lipogenesis and energy homeostasis. In cancer research, berberine hydrochloride downregulates the expression of c-IAP1, Bcl-2, and Bcl-XL, thereby promoting apoptosis. Moreover, berberine hydrochloride inhibits ferroptosis by activating the Nrf2/SLC7A11/GPX4 signaling pathway.
References:
[1] Yin J,Xing H,Ye J. Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism.2008 May;57(5):712-7.
[2] Gao CR,Zhang JQ,Huang QL. Experimental study on berberin raised insulin sensitivity in insulin resistance rat models. Zhongguo Zhong Xi Yi Jie He Za Zhi.1997 Mar;17(3):162-4.
| Storage | Store at -20°C |
| M.Wt | 371.81 |
| Cas No. | 633-65-8 |
| Formula | C20H18ClNO4 |
| Synonyms | Berberine Sulphate |
| Solubility | insoluble in H2O; ≥18.6 mg/mL in DMSO with gentle warming; ≥2.17 mg/mL in EtOH with gentle warming and ultrasonic |
| Chemical Name | 9,10-dimethoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium chloride |
| SDF | Download SDF |
| Canonical SMILES | COc(ccc1c2c[n+](CCc(c3c4)cc5c4OCO5)c-3c1)c2OC.[Cl-] |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
